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Y. Sun, X.–W. Wu, X. Zhang, X. Xu, Y. Gong; The relative influence on rod and cone system by diabetic retinopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4080.
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Purpose: To study the influence by DR on retinal photopic and scotopic components. Methods: 49 diabetic patients, 89 eyes were selected and divided into 4 groups by the changes under fluorescein angiography (FA): without changes(group 1), with changes but without nonperfusion area or neovascular leakage(group 2), with nonperfusion area but without neovasucular leakage(group 3), with neovascular leakage but without vitreous haemorrhage or retinal detachment(group 4). All the eyes and 43 control eyes underwent Electroretinogram (ERG) recording according to the protocol of International Society for Clinical Electrophysiology of Vision. Heidelberg Engineering retinal angiography were used to study the FA changes. ERG were recorded using UtasE–2000 visual electro–physiological diagnostic system. Results:Compared with control, the amplitude of flicker response begins to reduce in group 1 and the amplitude of scotopic b–wave response begins to reduce in group 3. In group 4 the amplitude of both scotopic b–wave and flicker response reduce further compared with group 3, but with the former reduces more significantly. Compared with control, the ratio of scotopic b–wave amplitude and flicker amplitude rises in group 1 and continues rising in group 2 and group 3, but declines in group 4. Conclusions: Rod and cone system are both affected by DR, with the latter more sensitive in pre–clinical stage and relatively more severely affected in early DR. But the function of the former grows more deteriorated in late DR.
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