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S. Sakurai, Y. Shimada, T. Sugino, N. Horio, M. Horiguchi; Pre– and postoperative multifocal ERGs in patients with diabetic maculopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4098.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To assess retinal macular function before and after vitrectomy for diabetic maculopathy with multifocal electroretinogram (mfERG). Methods: Sixteen diabetic patients (16 eyes, mean 64.0 ± S.D. 7.4 years old) with diabetic maculopathy who underwent vitrectomy served as subjects. MfERGs (37 stimulus patches, VERISTM, EDI Inc., CA) and macular thickness (OCT, optical coherent tomography) were measured before and 24–month after vitrectomy. Focal ERG from the central area (central ERG) and sum of all (37 stimulus patches) focal ERGs (total ERG) were obtained. The amplitude and peak time of the b–wave were analyzed. The ratio of the amplitude of central ERG to that of total ERG (C/T ratio) was calculated, and preoperative and postoperative visual acuity (logMAR, preVA and postVA, respectively) were analyzed. Results: PostVA was significantly better than PreVA (pre–op: 0.63±0.24, post–op: 0.38±0.29, p<0.01). After the vitrectomy, macular thickness was drastically reduced (pre–op: 421±147 µm, post–op: 205±124 µm, p<0.01). Both central and total ERG were reduced significantly in amplitude and slightly shortened in peak time (amplitude, total mfERG; pre–op: 7.70±2.53 µV, post–op: 5.54±2.23 µV, p<0.01, central ERG; pre–op: 158±57.0 nV, post–op: 127±56.7 nV, p<0.01, peak time, total mfERG; pre–op: 30.9±1.79 msec, post–op: 30.2±2.90 msec, p=0.16, central ERG; pre–op: 30.7±2.83 msec, post–op: 29.4±2.91 msec, p=0.15), C/T ratio was significantly increased (pre–op: 0.021±0.005, post–op: 0.024±0.007, p=0.037). Conclusions: Vitrectomy reduced macular edema and improved visual acuity. However, the amplitude of mfERG was reduced. Amplitude reduction without delay of peaktime may not suggest dysfunction of the retinal neurons but decreased number of neurons. Increased C/T ratio may suggest relative survival of macular neurons.
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