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P. Turchetti, E. Pacella, F. Pacella, F. Bozzoni Pantaleoni, C. Balacco Gabrieli; The role of adrenomedullin in diabetic retinopathy. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4107.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To evaluate the significance of adrenomedullin high levels in diabetic retinopathy as an indicator of retinal microvascular dysfunction in diabetes. Methods:We analysed the adrenomedullin levels in 32 non insulin dependent diabetes mellitus patients (mean age 63±8), and in 20 healthy subjects (mean age 60±8). The diabetic patients were divided into two groups on indirect biomicroscopy of the fundus. The first group presented various degrees of diabetic retinopathy. The second group did not show diabetic retinopathy. The levels of glycosylated haemoglobin (HbA1c) were also measured in all the patients. Results:The patients with diabetes showed non significant (p=0.078) higher adrenomedullin levels (126.51±69.12 pg/ml) in comparison with the healthy subjects (85.33±32.59 pg/ml). No correlation was found between adrenomedullin and HbA1c. Indeed, statistically significant (p=0.008) higher adrenomedullin levels were found in the group of patients with diabetic retinopathy (144.36± 52.31 pg/ml) compared with the lower adrenomedullin levels (85.33±32.59 pg/ml) of the healthy group. Conclusions:This study shows that there is no correlation between adrenomedullin and glicemia. Adrenomedullin may be considered as an indicator of retinal damage and as a marker of retinopathy progression.
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