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T. Asano, M. Kondo, N. Kondo, C.–H. Piao, H. Terasaki, Y. Miyake; Diagnostic Usefulness of Full–field ERGs and Multifocal ERGs in Acute Zonal Occult Outer Retinopathy (AZOOR) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4242.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Acute zonal occult outer retinopathy (AZOOR) is a retinal disease characterized by acute visual disturbance with minimal or no visible fundus abnormality (Gass, 1992; 2003). The electroretinogram (ERG) is known to be very important to diagnose this disorder. We compared the diagnostic usefulness of conventional full–field ERGs and multifocal ERGs in diagnosing AZOOR. Methods: Fifteen consecutive patients with AZOOR, who were seen in Nagoya University Hospital from 1995 to 2003, were studied. Fourteen cases had unilateral involvement, and one was bilateral. We analyzed three values, and investigated whether they were within the normal range (>5 percentile of normal controls). (1) Amplitude of full–field ERGs (recommended by International Society of Clinical Electrophysiology of Vision) in the affected eye. (2) Ratio of the amplitude in the affected eye to the unaffected eye for the full–field ERGs. And (3), the amplitude of the focal response of the multifocal ERG in the affected eye. Results: Eight of 15 patients (53%) showed a significant amplitude reduction of the full–field ERGs in the affected eye. Eleven of 14 patients with unilateral involvement had abnormally large differences in the amplitude of the full–field ERGs in the two eyes. The remaining three patients had relatively small retinal areas affected. In contrast, all 15 patients demonstrated significantly reduced local responses in the retinal areas which corresponded to visual field defects. Conclusions: About 80% of AZOOR patients can be diagnosed using conventional full–field ERGs. The multifocal ERG technique is also a sensitive diagnostic tool for AZOOR patients, especially when patients have a relatively small retinal area involved.
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