May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Systemic Acetazolamide, Ocular Hemodynamics and Retinal Vessel Diameters in Healthy Volunteers
Author Affiliations & Notes
  • K.G. Schmidt
    Ophthalmology, University of Dresden, Dresden, Germany
  • M. Müller
    Ophthalmology, University of Dresden, Dresden, Germany
  • A.G. Böhm
    Ophthalmology, University of Dresden, Dresden, Germany
  • L.E. Pillunat
    Ophthalmology, University of Dresden, Dresden, Germany
  • Footnotes
    Commercial Relationships  K.G. Schmidt, None; M. Müller, None; A.G. Böhm, None; L.E. Pillunat, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4434. doi:
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      K.G. Schmidt, M. Müller, A.G. Böhm, L.E. Pillunat; Systemic Acetazolamide, Ocular Hemodynamics and Retinal Vessel Diameters in Healthy Volunteers . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4434.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: This study was designed to evaluate for the influence of the systemic carbonic anhydrase inhibitor acetazolamide on small retinal vessel diameters and ocular as well as systemic perfusion parameters on healthy volunteers. Methods: 8 healthy volunteers (26.6 ± 5.5 years; 6 males, 4 females) received acetazolamide (1000mg) orally. Baseline measurements were performed 15 minutes before drug application (T0) and parameters were determined as follows: Intraocular pressure (IOP, Goldmann), pulsatile ocular blood flow (POBF, OBF–System, OBF Labs U.K.), retinal capillary blood flow (RCBF, HRF–System, Heidelberg Engineering, Heidelberg, Germany), retinal arteriolar diameters (RAD, Retinal Vessel Analyzer, RVA; Imedos GmbH, Weimar, Germany) and systemic perfusion parameters (systolic and diastolic blood pressures, heart rate (HR)). The exact same measurements were performed at T15 (T0+15min), T30, T45, T60 and T75, respectively. Results: IOP was altered as folllows: T0 (14.3 ± 2.9 mm Hg), T15 (– 2.8%, p > 0.1), T30 (– 21.9%, p = 0.053), T45 (– 22.6%, p = 0.04), T60 (– 30%, p = 0.01) and T75 (– 25.9%, p = 0.03). All other parameters investigated were not (sig.) altered during the course of this experiment. Maximum change in RCBF (+ 45.4 %, p = 0.081), RAD (+ 3.6 %, p = 0.075) and HR (– 3.6 %, p = 0.054) was at T45. Conclusions: Results indicate an increase in retinal microcirculation following application of the systemic carbonic anhydrase inhibitor acetazolamide and efficient chorioidal autoregulation in young healthy volunteers.

Keywords: blood supply • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • clinical research methodology 
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