IOP variability in POAG patients that reached target IOPs

Abstract

Abstract: : Purpose: To study intraocular pressure (IOP) variability in primary open angle glaucoma (POAG) patients under clinical treatment who reached established target pressure based on isolated office readings. Methods: Retrospective analysis of 65 eyes from 65 POAG patients under clinical therapy who were submitted to modified diurnal tension curve (DTC) (measurements at every 3 hours between 8 AM and 17 PM) followed by a water drinking test (WDT). All subjects had established target IOP ≤ 15 mmHg at 11 AM and (or) 2 PM. IOP variability during DTC or WDT was evaluated.Results:DTC revealed IOP measurements at least 2 mmHg higher than 15 mmHg in 14 of 65 eyes (21.5%), with 8 eyes (12.3%) presenting values ≥ 18mmHg. WDT demonstrated IOP values ≥ 17 mmHg in 32 eyes (49.23%). During this test 14 eyes (21.5%) reached IOP ≥ 20 mmHg. 36 patients (55.4%) showed IOP measurements at least 2mmHg higher than 15 mmHg in DTC or WDT.Conclusion: A great percentage of POAG patients under clinical therapy and with IOP control based on single office measurement presents significantly higher IOP measurements when performing modified diurnal tension curve and water drinking test.

Keywords: outflow: trabecular meshwork • intraocular pressure • clinical (human) or epidemiologic studies: risk factor assessment