Purchase this article with an account.
L.M. Tong, S. Saw, G. Gazzard, J.–K. Siak, D. Tan; Corneal thickness and intraocular pressure in Singapore children . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4496.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine the central cornea thickness(CCT) in Singapore children and to examine the possible relationship between intraocular pressure (IOP) and other biometric factors and CCT. Methods: This is a cross sectional study obtained from the Singapore Cohort study Of the Risk factors for Myopia (SCORM) in Singapore. The subjects’ ages (n=652) ranged from 9 to 11 years old. There were 485 Chinese, 92 Malay and 75 Asian Indian children. Measurement procedures included air puff tonometry, non–contact slit lamp Haag Streit optical pachymetry, cycloplegic autorefraction and autokeratometry using the Canon RK5 autorefractokeratometer.. The test–retest repeatability of pachymetry was –0.04 microns (95%CI: –5.33 to +5.25). Results: The mean corneal thickness was 543.6 microns (SD: 32.0). Chinese children have thicker corneas than Malay or Indian children (p=0.002). The boys had a statistically thicker cornea than girls (p=0.011), but the mean difference was only 6.4 microns. There was high correlation of CCT (r=0.98) and IOP(r=0.88) between right and left eyes. IOP was correlated significantly with CCT (r = 0.45, p<0.001). CCT increased from a mean of 527.2 microns in the first IOP quartile (10.7–15.3 mmHg) to 563.7 microns in the highest IOP quartile (19.1–24.7 mmHg). In a multiple linear regression model, each mmHg of intraocular pressure was associated with a corneal thickness difference of 5.90 microns (95%CI: 4.98, 6.82).Interestingly, the radius of corneal curvature was correlated inversely with CCT (r=0.19, p<0.001). The following parameters were not significantly (p>0.05) associated with CCT: age, family income, father’s education, axial length and spherical equivalent. Conclusions: The study supports previous findings in adults that there is a definite relationship between greater CCT and higher measured IOP. A change in CCT appeared to correlate with a greater difference in measured IOP compared to adults. There is a greater CCT in Chinese children compared to Malay and Asian Indian children in thismulti–ethnic population.
This PDF is available to Subscribers Only