May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Anterior Chamber Angles in Normal Chinese: A Comparison of Ultrasound Biomicroscopy, Scheimpflug and Gonioscopic Angle Assessment
Author Affiliations & Notes
  • G.M. Gazzard
    Singapore Eye Research Institute, Singapore
    Glaucoma Research, Institute of Ophthalmology, London, United Kingdom
  • D.S. Friedman
    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Baltimore, MD
  • P. Foster
    Glaucoma Research, Institute of Ophthalmology, London, United Kingdom
  • B.–M. Chan
    Singapore National Eye Centre, Singapore
  • J. Devereux
    Glaucoma Research, Institute of Ophthalmology, London, United Kingdom
  • A. Broman
    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Baltimore, MD
  • H. Quigley
    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Baltimore, MD
  • J. Tielsch
    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Baltimore, MD
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  • S. Seah
    Singapore National Eye Centre, Singapore
  • Footnotes
    Commercial Relationships  G.M. Gazzard, None; D.S. Friedman, None; P. Foster, None; B. Chan, None; J. Devereux, None; A. Broman, None; H. Quigley, None; J. Tielsch, None; S. Seah, None.
  • Footnotes
    Support  Supported by a grant from Johns Hopkins Singapore Pte. Ltd., and NIH K–23 EY–00358
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4498. doi:
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      G.M. Gazzard, D.S. Friedman, P. Foster, B.–M. Chan, J. Devereux, A. Broman, H. Quigley, J. Tielsch, S. Seah; Anterior Chamber Angles in Normal Chinese: A Comparison of Ultrasound Biomicroscopy, Scheimpflug and Gonioscopic Angle Assessment . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4498.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To investigate age and gender variations in the Ultrasound Biomicroscopy (UBM) characteristics of Chinese anterior chamber angles and compare with other evaluation techniques. Methods:268 subjects selected randomly from a population–based prevalence study in Singapore (Tanjong Pagar Glaucoma Survey) were assessed by UBM (840 Zeiss–Humphrey), Scheimpflug photography (Nidek EAS–1000), gonioscopy and optical pachymetry. The Angle Opening Distance 500µm from the scleral spur (AOD500) was determined objectively by image analysis with UBMPro2000 software. Results:Subjects in this subset study were older (mean age 58.7 years (SD 11.2)) than the original study (p<0.0001) but pachymetric central anterior chamber depth (ACD) and axial length were not different (age–adjusted p–value > 0.2). On UBM the temporal quadrant was the widest of the three studied (AOD500 = 0.073 µm, p < 0.05). The AOD500 was 0.034µm (47%) narrower in the inferior & 0.024µm (33%) shallower in the nasal quadrant than the temporal quadrant. Inferior, nasal and temporal angles all appeared narrower in females than males on UBM, but only significantly so in the temporal quadrant (mean 0.186µm versus 0.220µm). The inferior AOD 500 decreased significantly with age in males (p=0.03) and females (p=0.01), a trend more marked in women. There was also a non–significant tendency towards narrower temporal and nasal quadrants with age. ACD decreased with age (r = –0.18). UBM findings correlated better with gonioscopy (Spearman correlation coefficients 0.52 to 0.59, p < 0.0001) than with Scheimpflug (r = 0.31 to 0.37, p < 0.0001). All angle measurements correlated well with ACD (UBM r = 0.67; Scheimpflug photography r = 0.67; gonioscopy r = 0.75). Conclusion:This confirms, using UBM in a population based survey, the previous gonioscopic observations of angle narrowing with age and narrower angles in females and the strong correlation with central anterior chamber depth.

Keywords: clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • aging 
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