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M.T. Irkec, H.B. Cakmak, U. Erdener, B. Bozkurt, M. Orhan; Immunology of Lacrimal Fluid in Patients with Prosthesis–associated Giant Papillary Conjunctivitis (GPC) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4834.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate the underlying immunological and biochemical mechanisms in the pathogenesis of ocular prosthesis–GPC Methods: Tear samples of 40 patients (26 males and 14 females) with prosthesis–GPC were examined immunobiologically for immunoglobulin E (IgE), interleukin–2 receptor (IL–2R), and lactate dehydrogenase (LDH). Results: Prosthesis wearing–time in the study group ranged between 6 months and 12 years (mean ± SD; 26 ± 17 months). Tear fluid from eyes with GPC showed significantly higher levels of Ig E (106.7 ± 17.2 ng/ml), IL–2R (2178 ± 113.9 pg/ml and LDH (848.5 ± 108.6 U/l when compared with the control healthy fellow eyes (39.4 ± 13.6 ng/ml, 786.2 ± 91.6 pg/ml, and 416 ± 68.6 U/l, respectively)(p<0.05). Conclusions: The higher levels of IgE and IL–2R in tears from the patients demonstrated that both humoral and cellular immunity might play some role in the pathogenesis of prosthesis–GPC, a rather complex pathology. Increased tear LDH levels might be due to the leakage of the enzyme from the desquamated and lytic conjunctival epithelial cells and might be taken as evidence of trauma caused by the ocular prosthesis to the conjunctiva. Our study showed that the pathogenesis of prosthesis–GPC included both immunological and traumatic factors leading to the development of the conjunctival inflammation.
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