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M. Chapin, M.B. Abelson, K. Lane, P.J. Gomes; An Investigation of the Role of H3 Histamine Receptor Selective Antagonist Clobenpropit in the Compound 48/80 Model of Allergic Conjunctivitis in the Guinea Pig. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4850.
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Purpose:The involvement of H1 and H2 histamine receptors in ocular allergy has been investigated thoroughly. The purpose of this study was to investigate the role of H3 receptors in ocular allergy through treatment with Clobenpropit, a selective H3 receptor antagonist, in the Compound 48/80 model of allergic conjunctivitis in the guinea pig. Methods:Twelve Dunkin Heartly Guinea Pigs, (Cavia porcellus), all male and at least 4 weeks of age were used in this study. Guinea pigs were randomized to receive treatment with Clobenpropit 0.5% (N=6) or Clobenpropit 1.0% (N=6) in one eye and phosphate buffered saline (placebo) in the fellow eye. All guinea pigs were challenged bilaterally with 30mg/ml Compound 48/80. Bilateral ocular evaluations were performed at baseline and at 5, 15, 30 and 60 minutes post–challenge to assess global redness and chemosis using 5 point standardized scales. Results:Eyes treated with Clobenpropit 0.5% and Clobenpropit 1.0% exhibited lower median global redness scores and median chemosis scores as compared to placebo treated eyes at all assessment time points. Statistically significant differences were seen in the Clobenpropit 0.5% treatment group for redness (median difference=–0.5 at 30 minutes, P= 0.02) and for chemosis (median difference=–1.0 at 15 minutes, P=0.02). Conclusions:Topical application of Clobenpropit H3 receptor antagonist resulted in decreased median global redness and chemosis versus placebo. While results were statistically significant for only two assessment time points these findings suggest that H3 receptor antagonism may play a role in reducing allergy induced ocular congestion Further research is necessary to examine the H3 receptor as a therapeutic target for the treatment of allergic conjunctivitis.
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