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C. Vass, C. Hirn, E. Unger, W. Mayr, M. Georgopoulos, G. Rainer, S. Richter–Mueksch; Human aqueous humor viscosity in cataract, primary open angle glaucoma and pseudoexfoliation syndrome. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5030.
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Purpose: Viscosity of aqueous humor may be an important factor for glaucoma drainage implants with small inner diameter, which are designed for implantation into the Schlemm's canal. The purpose of this study is to measure the human aqueous humor viscosity of patients with primary open angle glaucoma (POAG), pseudoexfoliation syndrome (PEX) and cataract. Methods: We took aqueous humor samples of 15 patients with POAG, 12 patients with PEX, and 7 patients with cataract and no concomittant disease. Aqueous humor viscosity was measured with a specially constructed microviscosimeter, requiring only 80 microliter volume. The measurement was performed at 36 degree Celsius. For each sample the median of 20 separate measurements was determined. The groups were compared by means of t–tests. Results: The viscosities of the human aqueous humor were 0.7185 (+/– 0.0060), 0.7172 (+/– 0.0056) and 0.7206 (+/– 0.0068) for the POAG, PEX and cataract groups. There was no statistically significant difference between any of the 3 groups. Conclusions: Human aqueous humor viscosity of POAG and PEX did not differ significantly from the cataract control group. Viscosity of all three groups was significantly higher than water (0.7), but this difference was not clinically relevant.
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