Purchase this article with an account.
J.A. Kiland, B.T. Gabelt, P.L. Kaufman; Effect Of Age On Outflow Resistance Washout During Anterior Chamber Perfusion In Rhesus And Cynomolgus Monkeys . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5035.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine the effect of age on total outflow facility (OF) resistance washout in rhesus and cynomolgus monkeys. Methods: Total outflow facility (2–level constant pressure perfusion with Bárány's solution) was determined at baseline in one eye of 35 pentobarbital–anesthestized rhesus monkeys of both sexes aged 4–29 yrs. Total OF was also measured in 27 pentobarbital–anesthestized cynomolgus monkeys of both sexes, aged 3–17 yrs, at baseline and after 10 min AC exchange with 1 or 2 ml Bárány's perfusand, Bárány's containing 0.01–1% DMSO, or Bárány's containing Tris base. Results: Resistance washout did not differ significantly with age at baseline in rhesus or cynomolgus monkeys. Similarly, no significant changes were found when comparing post–exchange resistance washout vs. age in cynomolgus monkeys that had undergone AC exchange with Bárány's only, Bárány's containing 0.01–1% DMSO, or Bárány's containing Tris base. Conclusions: Resistance washout caused by 2–level constant pressure perfusion occurs at approximately the same rate regardless of age. Although total aqueous humor outflow facility has been found to decline with age in both cynomolgus and rhesus monkeys, we did not find a similar decline in outflow resistance washout with age.
This PDF is available to Subscribers Only