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E. Daniele, L. Carlomusto, L. Iacobelli, S. Putano, P. Grenga, E. Vingolo; Microperimetry evaluation in retinitis pigmentosa patients treated with omega 3 acid polyunsaturated. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5104.
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Purpose: Retinitis Pigmentosa is referred to genetically, clinically heterogeneous group of photoreceptors degenerations. Diagnostic charactheristics common to the major part of RP include a history of night blindness, visual field constricted, waxy pallor of the optic disc, subcapsular opacities of the lens and macular cistoid oedema. We analysed by microperimetry the retinic sensitivity before and after administration of omega 3 acid polyunsaturated. Methods: 15 patients (30 eyes), aged between 23 to 50, were studied after a complete ophthalmological examination for 6 months. All of them underwent ERG,PEV,FAG,visual field and microperimetry examinations. An informed consent was obtained. We gave them for a period of 6 months omega 3 acid polyunsaturated(530mg; 160 DHA, 230EPA), co–enzyme Q10 (10 mg) and Acetil–L–carnitina (100 mg) twice a day. Then to evaluate decibel variations in sensitivity of the retina we performed a microperimetry analisis after 6 months(NIDEK MP1), with a normal spot of fixation and with a program 10–2 like Humphrey, evaluating the sensitivity of the different points studied and the stability of fixation. Results: After 6 months 3 eyes (10%) had a decrease of 2 decibel from the initial value; 12 eyes (40%) were unchanged; 15 eyes had an increase major of 2 db from the beginning. Conclusions: On the basis of our preliminary results is evident a positive effect of therapy mentioned above on the retinic methabolism. probable mechanisms of action are: improve methabolic demands of photoreceptors, in according to Stone theory a stop or a lowering of the apoptotic effects, a positive effect on the phototransduction mechanism (for example: an increase in the inactivation of Rhodopsin, a major activity of the transducin, a major efficiency of the guanilato–cyclase, a positive effect on the frequent conformational changes of the rhodopsin). So we can say, that this kind of therapy is useful to obtain a recovery damages of the photoreceptors, contributing to stabilize clinical conditions of RP patients. Our study is not conclusive, but is an attempt to evaluate the effects of a conservative therapy in the tapetoretinal degenerations. Our goal is to evaluate the real effects of medical therapy in a period of 3–5 years. Tubilux Pharma Grant n°1
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