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M.L. Livani, E. Rispoli, R.H. F. Mendonça, C. Morini, E.M. Vingolo; OCT and EOG abnormalities in families with X–linked Retinitis Pigmentosa . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5105.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To determine the correlations between morphological (optical coherence tomography – OCT) and electrophysiological (electro–oculogram EOG) alterations in families with X–linked retinitis pigmentosa. Methods:Sixteen members of 4 different families: 7 obligate carriers, 4 affected male homozygote and 5 not affected females, underwent ophthalmological completed exams including EOG and OCT. All the subjects are previously tested with genetic analysis. Results:The abnormalities in OCT were detected in all carriers and affected males contrasting with no alterations in not affected females. The EOG was flat in all affected males. Distinctly subnormal in 8 eyes of obligate carries. Normal in 2 eyes of obligate carriers and in all not affected females. In two obligate carriers, the EOG was not performed due to a nuclear cataract. The correlations between OCT and EOG alterations were statistically significant. Conclusions: The OCT and EOG demonstrated to be a very sensible methods to identified the minimal alterations in carriers of X–linked Retinitis Pigmentosa.
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