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M.S. Ying, J.J. Fuller, J. Alexander, W.C. Sheils, Y. Lee, D.M. Marcus; Multimodality Transpupillary Thermotherapy and Radiotherapy of Occult Subfoveal Choroidal Neovascular Membranes in Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5136.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To determine the safety and efficacy of combined transpupillary thermotherapy (TTT) and external beam radiation (EBR) for occult subfoveal choroidal neovascular membranes (CNV) in age–related macular degeneration (AMD). Methods: Eight patients with AMD–related occult subfoveal CNV and vision 20/400 or better were prospectively enrolled in a Phase I safety study. Delivery of one or more spots of TTT to cover the CNV lesion was applied with a diode laser (810 nm, spot size–3.0 mm, 60 sec., power–600–800mW). EBR was initiated within five hours after TTT and was delivered in 5 daily fractions of 4 Gy (20 Gy total dose). ETDRS–BCVA, fluorescein angiography and fundus photography were performed at baseline and prospectively determined follow–up periods. Photographic and angiographic data (type and size of CNV and degree of fibrosis/hemorrhage) were graded by the Scheie Photographic Reading Center. Results:
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