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T. Tanaka, S. Saika, K.–I. Miyazaki, Y. Ohnishi; Expression of growth factors and matrix macromolecules in uveal melanoma . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5202.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To examine the expression patterns of growth factors in human uveal melanoma. Matrix molecules that are reportedly involved in growth factor deposition were also localized. Methods: Deparaffinized sections were processed for immunofluorescence immunohistochemistry. Antibodies against connective tissue growth factor, transforming growth factor–beta1, 2, or 3, macrophage chemotactic protein–1, or vascular endothelial growth factor were investigated. Localization of extracellular matrix components, i. e., various collagen types and osteonectin, were also examined. Results: Various growth factor proteins like connective tissue growth factor were detected in either cells or marix. Matrix substance were labeled for collagen IV and osteonectin. Conclusions: Cells in uveal melanoma express various growth factros. Such factors are considered to be deposited in the extracellular matrix.
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