May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Neuroendocrine Choroidal Melanoma
Author Affiliations & Notes
  • C.H. Pastore
    Ophthalmology, Hospital Carlos G Durand, Faculty of Medicine, University of Buenos Aires, Argentina
  • D.E. Pelayes
    Ophthalmology, Hospital Carlos G Durand, Faculty of Medicine, University of Buenos Aires, Argentina
    Pathology, LIOCiV Laboratory of Ophthalmic Investigation and Visual Science, Faculty of Medicine, University of Buenos Aires, Argentina
  • D. Colombero
    Ophthalmology, Hospital Carlos G Durand, Faculty of Medicine, University of Buenos Aires, Argentina
  • N. Lago
    Pathology, LIOCiV Laboratory of Ophthalmic Investigation and Visual Science, Faculty of Medicine, University of Buenos Aires, Argentina
    Pathology, Faculty of Medicine, University of Buenos Aires, Argentina
  • B. Corcostegui
    IMO, Ocular Microsurgery Institute, Barcelona, Spain
  • G. Piantoni
    Ophthalmology, Hospital Carlos G Durand, Faculty of Medicine, University of Buenos Aires, Argentina
    Pathology, LIOCiV Laboratory of Ophthalmic Investigation and Visual Science, Faculty of Medicine, University of Buenos Aires, Argentina
  • J.O. Zarate
    Pathology, LIOCiV Laboratory of Ophthalmic Investigation and Visual Science, Faculty of Medicine, University of Buenos Aires, Argentina
    Pathology, Faculty of Medicine, University of Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  C.H. Pastore, None; D.E. Pelayes, None; D. Colombero, None; N. Lago, None; B. Corcostegui, None; G. Piantoni, None; J.O. Zarate, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 5206. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      C.H. Pastore, D.E. Pelayes, D. Colombero, N. Lago, B. Corcostegui, G. Piantoni, J.O. Zarate; Neuroendocrine Choroidal Melanoma . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5206.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: Due to its embryologic origin, neuroendocrine tumors may arise from melanocytic lesions. The aim of our communication is to identify cases of neuroendocrine differentiation in a series of choroidal melamonas. Methods: A total of 242 enucleated eyes examined between 1972 and 2003 , were analyzed. Small type cell melanomas with neuroendocrine differentiation (MND) were studied with immunohistochemistry (IHC) and transmission electron microscopy (TEM). IHC techniques included S–100, HMB 45, chromogranine, synaptophysin, calcitonine and vasoactive peptide (VIP)and and one case with transmission electron microscopy (TEM). Results: Three melanomas with neuroendocrine differentitation were found by cytology, histoarquitectural features (fasciculated – organoid with rosettes – lumen–like), IHQ and TEM . Conclusions: Our results using IHQ and TEM indicates that choroidal melanomas may show different patterns of neuroendocrine lineage. Fascicular neuroendocrine melanoma of the choroid has not been previously described in the literature.

Keywords: oncology • melanoma • pathology: human 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×