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C.H. Pastore, D.E. Pelayes, D. Colombero, N. Lago, B. Corcostegui, G. Piantoni, J.O. Zarate; Neuroendocrine Choroidal Melanoma . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5206.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Due to its embryologic origin, neuroendocrine tumors may arise from melanocytic lesions. The aim of our communication is to identify cases of neuroendocrine differentiation in a series of choroidal melamonas. Methods: A total of 242 enucleated eyes examined between 1972 and 2003 , were analyzed. Small type cell melanomas with neuroendocrine differentiation (MND) were studied with immunohistochemistry (IHC) and transmission electron microscopy (TEM). IHC techniques included S–100, HMB 45, chromogranine, synaptophysin, calcitonine and vasoactive peptide (VIP)and and one case with transmission electron microscopy (TEM). Results: Three melanomas with neuroendocrine differentitation were found by cytology, histoarquitectural features (fasciculated – organoid with rosettes – lumen–like), IHQ and TEM . Conclusions: Our results using IHQ and TEM indicates that choroidal melanomas may show different patterns of neuroendocrine lineage. Fascicular neuroendocrine melanoma of the choroid has not been previously described in the literature.
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