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A. Loewenstein, PHP Research Group; Monitoring Myopic Choroidal Neovascularization (CNV) Patients Following Photodynamic Therapy (PDT), utilizing Preferential Hyperacuity Perimetry (PHP) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5455.
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Purpose:Conventional Post–PDT follow–up methods are based on either anatomical or physiological properties of the entire macula (biomicroscopy, fluorescein angiography and various imaging devices), or on functional measurements of the fovea only (visual acuity or contrast sensitivity). Functional measurements of the macular area may refine treatment guidelines. our Aim was to Evaluate the correlation between changes in PHP visual field defects and changed revealed by existing follow–up modalities: FA and VA. Methods:The PHP is a visual field test for measuring macular function in AMD, based on hyperacuity phenomenon. A dot deviation signal is flashed to the central 14° of the patient’s visual field, and perceived distortion or scotoma are recorded and automatically analyzed. A quantitative macular map of metamorphopsia is obtained. Five patients with CNV, secondary to Myopia, were examined before and 12 weeks after PDT. The correlation between FA and VA changes and PHP visual field map changes was examined. Results: In 4 out of 5 patients (80%), the PHP correlated with the change demonstrated by both FA &VA. In one patient (20%) there was a partial correlation (PHP and FA demonstrated the same change, while VA did not). All modalities (PHP, FA and VA) indicated that 2 patients deteriorated and 2 patients were stable. In one patient, PHP and FA improved, while VA remained stable Conclusions: Our results suggest that the PHP may be used to monitor myopic CNV patients following PDT. Frequent monitoring of myopic CNV patients may be necessary to provide scheduled, individualized treatment. PHP can serve as a tool to accomplish this goal. These preliminary results require further validation in a larger population and extended period of follow–up.
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