May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Test–retest variability of scanning laser polarimetry with variable corneal compensation is not affected by severity of glaucomatous damage.
Author Affiliations & Notes
  • H. Bagga
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL
  • W. Feuer
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL
  • D.S. Greenfield
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL
  • Footnotes
    Commercial Relationships  H. Bagga, None; W. Feuer, None; D.S. Greenfield, LDT R.
  • Footnotes
    Support  NIH R01 EY08684
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 5503. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      H. Bagga, W. Feuer, D.S. Greenfield; Test–retest variability of scanning laser polarimetry with variable corneal compensation is not affected by severity of glaucomatous damage. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5503.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To evaluate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness in normal eyes and eyes with pre–perimetric, early–moderate and advanced glaucomatous optic neuropathy (GON) using scanning laser polarimetry with variable corneal compensation (SLP–VCC). Methods: Complete examination, standard achromatic perimetry (SAP), and SLP–VCC imaging of the peripapillary retina were performed. GON was defined as cup/disc asymmetry between fellow eyes of greater than 0.2, rim thinning, notching, excavation, or RNFL defect and was classified by the following groups: pre–perimetric (normal SAP), early–moderate (MD <12dB) and advanced (MD ≥ 12 dB). Exclusion criteria were visual acuity < 20/40, diseases other than glaucoma, and unreliable SAP. Abnormal SLP–VCC measurements were defined as a cluster of ≥ 3 contiguous superpixels outside 95% normal limits with 1 outside 99% normal limits, or any retardation parameter outside 95% normal limits. A series of 3 measurements were obtained on a single day and 3 separate measurements on 3 separate days within a 3–month period. Intrasession and intersession reproducibility were evaluated using an intraclass correlation coefficient. Results: 47 eyes of 47 patients (12 normal, 15 pre–perimetric GON, 10 early–moderate GON, and 10 advanced GON) were enrolled (mean age 60 ± 18 years, range 25 –88). All eyes with glaucoma had associated visual field abnormalities (average MD = –0.5 ± 1.3, –0.6 ± 1.5, –5.4 ± 3.0, –26.3 ± 5.0 dB for normals, pre–perimetric, early–moderate and advanced GON respectively). The intraclass coefficients of intrasession reproducibility of TSNIT average and NFI were 94% and 86%; 98% and 93%; 96% and 94%; and 98% and 98% for normals, pre–perimetric, early–moderate and advanced GON respectively. The intraclass coefficients of intersession reproducibility were 94% and 89%; 78% and 84%; 92% and 94%; and 95% and 96% for normals, pre–perimetric, early–moderate and advanced GON respectively. The location and extent of RNFL loss on the retardation map was repeatable in 12/15 (80%), 8/10 (80%) and 8/10 (80%) eyes of pre–perimetric, early–moderate and advanced GON respectively. Conclusions: SLP–VCC provides high level of reproducibility in normal and glaucomatous eyes. Test–retest variability is not affected by the severity of glaucomatous damage.

Keywords: imaging/image analysis: clinical • nerve fiber layer 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×