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H.G. Lemij, N.J. Reus; The Relationship between Standard Automated Perimetry, GDx VCC, and HRT . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5510.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To investigate the relationships between standard automated perimetry (SAP), peripapillary retinal nerve fiber layer (RNFL) thickness measured with the GDx VCC, and optic nerve rim area measured with the HRT. Methods: We measured one eye each of 35 healthy subjects and 53 glaucoma patients with SAP (Humphrey Field Analyzer, Carl Zeiss Meditec, Dublin, CA, USA), GDx VCC with automated individualized compensation of anterior segment birefringence (Laser Diagnostic Technologies, Inc., San Diego, CA, USA), and HRT I (Heidelberg Engineering, GmbH, Dossenheim, Germany). Visual field test points, peripapillary GDx VCC measurements, and HRT measurements of rim area were grouped into 6 corresponding sectors, based on their anatomical relationships published by Garway–Heath et al. (Ophthalmology 2000;107:1809–1815). We determined the degree of correlation between SAP, GDx VCC, and HRT with Spearman’s rank correlation coefficient (ρS). Results: We found a linear relationship between HRT and GDx VCC measurements (ρS, 0.36–0.79; p value, ≤0.001). The relationship between GDx VCC measurements and SAP was curvilinear for all sectors (ρS, 0.42–0.79; p value, <0.001) except for the temporal one (ρS, 0.14; p value, 0.18). The relationship between HRT measurements and SAP was curvilinear for all sectors (ρS, 0.48–0.80; p value, <0.001), except for the nasal one (ρS, 0.28; p value, 0.007). Conclusions: Both GDx VCC measurements of the peripapillary RNFL and HRT measurements of rim area relate well with functional glaucomatous loss. The observed curvilinear relationships between function and structure suggest that glaucomatous damage to the nerve fibers may be detected with both the GDx VCC and the HRT before clinically significant visual field damage occurs. In addition, mild to moderate glaucomatous loss might be better monitored with the GDx VCC and/or HRT, whereas severe glaucomatous loss might be better followed with SAP.
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