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D.M. Iihama, L.M. Pinto, L.A. S. Melo Jr, B.M. Fontes, L.M. Doi, R.A. B. Lobo, A. Paranhos; A Randomized Clinical Trial Comparing The Intraocular Pressure Changes With The Use Of Loteprednol And Dexamethasone After Pterygium Surgery . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5546.
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Purpose:To compare the intraocular pressure (IOP) changes after pterygium surgery between patients using loteprednol and dexamethasone in the postoperative period. Methods:A 6–week randomized clinical trial was performed involving 35 patients who underwent pterygium surgery with conjunctival autograft transplantation. After the surgery, the patients were randomly assigned in two groups. The patients in Group I used loteprednol etabonate 0.5% and in Group II received dexamethasone 0.1% eyedrops. In both groups the corticosteroids were used for 4 weeks: 4 times a day in the first week and tapered off one drop a week thereafter. The IOP was measured before surgery and once–weekly for the first 4 weeks and at 6 weeks after the surgery. Results:The IOP increased in both groups after the surgery (Group I – 4.1 ± 2.3 mmHg (p<0.001); Group II – 5.0 ± 3.2 mmHg (p<0.001)), which returned to preoperative levels after the 4th postoperative week. It was not found a statistically significant difference (p=0.370) of IOP increases between these two groups. Conclusions: Transient IOP increase occurs in patients using loteprednol and dexamethasone after pterygium surgery, but there is no difference in IOP increase between these two corticosteroids.
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