May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Choroidal Hemodynamics Correlates to Visual Function in Humans
Author Affiliations & Notes
  • H. Garzozi
    Ophthalmology, Bnei Zion Hospital, Haifa, Israel
  • A. Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • L. McCranor
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • L. Kagemann
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • S. Friedman
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • R. Kumar
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • B. Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • Footnotes
    Commercial Relationships  H. Garzozi, None; A. Harris, None; L. McCranor, None; L. Kagemann, None; S. Friedman, None; R. Kumar, None; B. Siesky, None.
  • Footnotes
    Support  Unrestricted Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 155. doi:
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    • Get Citation

      H. Garzozi, A. Harris, L. McCranor, L. Kagemann, S. Friedman, R. Kumar, B. Siesky; Choroidal Hemodynamics Correlates to Visual Function in Humans . Invest. Ophthalmol. Vis. Sci. 2003;44(13):155.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To correlate peripapillary and perimacular choroidal hemodynamics to visual function in humans. Methods: All procedures were approved by an IRB, and informed consent obtained. Fifteen healthy persons (27.3 ± 8.9 years, 12 male, 3 female) were recruited for this randomized, cross-over double blind placebo controlled study. Two areas in the temporal peripapilar region and four areas in the perifoveal region were analyzed with indocyanine green scanning laser ophthalmoscope angiography (Rodenstock SLO (SLO 101, Rodenstock GmbH, Munich Germany) on a randomly chosen eye at baseline and two hours after administration of the assigned treatment. Treatments included 30 mg nicergoline, 60 mg nicergoline, or placebo. Visual acuity (VA) and contrast sensitivity (CS) were also measured by ETDRS logMAR chart and CSV 1000, respectively. Baseline and post-drug values were compared by ANOVA. Linear regression analysis was used to determine the correlation between blood flow and visual function. Results: Acute administration of nicergoline did not significantly effect choroidal circulation or visual function compared to placebo. However, both VA and CS correlated significantly with choroidal filling characteristics for both 30 mg and 60 mg doses of nicergoline (p≤ 0.0436, r2 ≥ 0.624). Conclusions: A statistically significant correlation between choroidal filling time and CS were demonstrated. This suggests possible associations between peripapillary and perimacular hemodynamics with visual function.

Keywords: blood supply • imaging methods (CT, FA, ICG, MRI, OCT, RTA, S 
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