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H. Garzozi, A. Harris, L. McCranor, L. Kagemann, S. Friedman, R. Kumar, B. Siesky; Choroidal Hemodynamics Correlates to Visual Function in Humans . Invest. Ophthalmol. Vis. Sci. 2003;44(13):155.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To correlate peripapillary and perimacular choroidal hemodynamics to visual function in humans. Methods: All procedures were approved by an IRB, and informed consent obtained. Fifteen healthy persons (27.3 ± 8.9 years, 12 male, 3 female) were recruited for this randomized, cross-over double blind placebo controlled study. Two areas in the temporal peripapilar region and four areas in the perifoveal region were analyzed with indocyanine green scanning laser ophthalmoscope angiography (Rodenstock SLO (SLO 101, Rodenstock GmbH, Munich Germany) on a randomly chosen eye at baseline and two hours after administration of the assigned treatment. Treatments included 30 mg nicergoline, 60 mg nicergoline, or placebo. Visual acuity (VA) and contrast sensitivity (CS) were also measured by ETDRS logMAR chart and CSV 1000, respectively. Baseline and post-drug values were compared by ANOVA. Linear regression analysis was used to determine the correlation between blood flow and visual function. Results: Acute administration of nicergoline did not significantly effect choroidal circulation or visual function compared to placebo. However, both VA and CS correlated significantly with choroidal filling characteristics for both 30 mg and 60 mg doses of nicergoline (p≤ 0.0436, r2 ≥ 0.624). Conclusions: A statistically significant correlation between choroidal filling time and CS were demonstrated. This suggests possible associations between peripapillary and perimacular hemodynamics with visual function.
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