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N. Pahms, A. Liekfeld, N. Torun, C. Hartmann; The Influence of a Specific IOL Rim Structure on PCO - In Vitro Study on a Human Capsular Bag System . Invest. Ophthalmol. Vis. Sci. 2003;44(13):285.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: to figure out , whether the surface causes differences in posterior capsular opacification (PCO), we compare the growth of lens epithelial cells (LEC)in two different intraocular lenses (IOL). One of these silicone lenses (AcriSil73N) has a specific optical rim structure (fresnell-structure), which provides a reduction of overall IOL thickness as advantage for small-incision cataract surgery. The second lens is a thicker traditional one (701S), identical in design exept of the rim structure, specially manufactured for these experiments. Methods:Sham cataract surgery, including anterior capsulorhexis, nucleus hydroexpression, and aspiration of lens fibers, was performed on 12 donor eyes (6 pairs) after removing the cornea. In each eye of one pair an ultrathin, monofocal IOL with specific optical rim structure (AcriSil73N) was implanted. In the other eye we implanted a traditional formed smooth lens (701S) of the same design without the rim structure. The capsular bag including the lens was dissected free, pinned flat on a culture dish, covered with medium and incubated. The time period needed for a confluent monolayer of LEC on the posterior capsule was documented. Results: On average the posterior capsule in the capsular bags with an AcriSil73N was covered by a confluent monolayer after 7.8 days. However in the capsular bags with a 701S after 8.5 days a LEC monolayer was observed. Conclusions: Although the ultrathin AcriSil73N IOL with specific rim structure has advantages for small-incision surgery, it seems disadvantagous concerning PCO.
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