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M. Kojima, I. Hata, K. Wake, S. Watanabe, K. Sasaki, M. Taki, Y. Yamanaka, Y. Kamimura, N. Takahashi; The Relationship Between Experimental Room Temperature and Lens Changes and Ocular Inflammation Induced by Microwave Exposure . Invest. Ophthalmol. Vis. Sci. 2003;44(13):295.
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Purpose: To clarify the relationship between experimental room temperature and light scattering changes of lenses and ocular inflammation induced by microwave radiation in rabbits. Methods: Forty-three male pigmented rabbits (Dutch, 1.8-2.2 kg) were systemically anesthetized with ketamine hydrochloride (5 mg/kg, im) + xylazine (0.23 mg/kg, im). The eyes were exposed unilaterally to a 2.45 GHz microwave for 100 minutes (100, 300 mW/cm2) under either a low room temperature of 20 degrees centigrade or a high room temperature of 30 degrees centigrade. Changes in the anterior segment were observed by a Scheimpflug image analysis system, and a laser flare cell meter. The temperatures of the eye segments were measured during microwave exposure by a Fluoroptic Thermometer. Results: In the 30 degree centigrade group, the irradiated eyes showed miosis, conjunctival hyperemia, corneal edema, and an increase in the light scattering of the anterior shallow cortex in the pupillary area of the lens. The 20 degree centigrade group showed much lighter changes than the 30 degree centigrade group. All of the changes in both groups of rabbits disappeared within a week. The highest temperature during exposure was seen in the vitreous, followed by the anterior chamber, and the retrobulbar cavity of the orbit. The above mentioned ocular changes and ocular temperature corresponded with room temperature. Conclusions: The acute high intensity of microwave exposure temporally induced anterior segment inflammation and lens changes. The influence of experimental room temperature on ocular changes should be considered.
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