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D.B. Pedersen, E. Stefánsson, T. Eysteinsson, J.F. Kiilgaard, M. la Cour, K. Bang, P.K. Jensen; Optic Nerve Oxygen Tension: The Effect of Indomethacin . Invest. Ophthalmol. Vis. Sci. 2003;44(13):334.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Non-steroid anti-inflammatory drugs (NSAID) such as ibuprofen and indomethacin are widely used in the treatment of pain and inflammatory diseases. It is controversial if NSAIDs affect blood flow in the brain and the eye. We investigated how indomethacin affects the optic nerve oxygen tension in the pig. Methods: Optic nerve oxygen tension (ONPO2) was measured in 5 pigs (Danish landrace, approx. 30 kg) with a polarographic oxygen electrode mounted with an internal Ag/AgCl reference electrode inside a 20-gauge needle (model 768-20R, Diamond General Development Corporation, Ann Arbor, MI, USA). The tip of the electrode was placed in the vitreous humour 0.5 mm above the optic disc. 300 mg indomethacin (Bie & Berntsen A/S) was dissolved in isotonic sodium chloride and injected intravenously. ONPO2, arterial blood pressure, heart rate and arterial blood gasses were recorded continuously. The treatment of the pigs followed the ARVO resolution for the use of animals in ophthalmic and vision research. Results: Baseline ONPO2 (mean ± SD) was 2.96 ± 0.59 kPa (n=5) while blood PO2 was 12.06 ± 0.85 kPa. Administration of 300 mg indomethacin decreased ONPO2 by –1.22 ± 0.43 kPa (p=0.003) to 1.77 ± 0.36 kPa after 60 min. Mean arterial pressure increased initially but had returned to baseline after 60 min. Heart rate, arterial pH, PCO2 and PO2 were constant throughout the experiment. Conclusions: Systemic administration of NSAID causes a decrease in ONPO2, probably due to decreased blood flow through vasoconstriction of vessels in the optic nerve. It is likely to occur in the retina as well. This should be taken into account when treating patients suffering from retinal ischemic diseases such as diabetic retinopathy or glaucoma.
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