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E. Sato, T. Nagaoka, A. Takahashi, A. Yoshida; Effect of Interferon on Ocular Blood Flow . Invest. Ophthalmol. Vis. Sci. 2003;44(13):361.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To investigate the effect of systemic interferon (IFN) therapy on peripapillary retinal blood flow, optic nerve head blood flow, and choroidal blood flow in the foveal region.Methods:Seven eyes of seven patients with chronic hepatitis C were examined. We measured peripapillary retinal and optic nerve head blood flow by scanning laser Doppler flowmetry (SLDF, Heidelberg Retina Flowmeter) and choroidal blood flow by laser Doppler flowmetry (LDF, Oculix) before and 2 weeks after IFN therapy.Results:The blood flow in the peripapillary retina, optic nerve head, and choroid were, respectively, 214.9 ± 32.1, 249.5 ± 42.5, and 7.8 ± 1.3 arbitrary units (mean ± standard error) before IFN therapy, and 311.9 ± 37.5, 383.7 ± 35.0, and 8.1 ± 1.3 2 weeks after IFN therapy. The peripapillary retinal blood flow 2 weeks after IFN therapy significantly increased by 51.8 ± 17.1% (p<0.05). Although the optic nerve head blood flow tended to increase, the change did not reach significance. The choroidal blood flow also did not change significantly.Conclusions:These results indicate that systemic IFN therapy for patients with chronic hepatitis C may increase retinal blood flow. Furthermore, vascular responses induced by IFN may be different in the retina, the optic nerve head, and the choroid.
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