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S. Binder, I. Krebs, U. Stolba, C. Jahn, L. Kellner, H. Feichtinger, A. Abri, A. Assadoullina, B. Stanzel; Incidence of Recurrent Membrane Growth after Surgical Excision of Foveal Choriodal Neovascularization combined with Transplantation of Autologous Retinal Pigment Epithelium . Invest. Ophthalmol. Vis. Sci. 2003;44(13):486.
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Purpose: The number of recurrent choroidal neovascularisation (CNV) after membrane removal combined with simultaneous transplantation of autologous retinal pigment epithelium (RPE) was evaluated clinically, by fluorescein angiography and indocyanine green angiography (Heidelberg Retina Angiograph ) Design: Retrospective observational study Material and Methods: In a retrospective analysis eyes which underwent transplantation of autologous RPE at the time of the excision of a foveal CNV were evaluated. A minimal observation time of 12 months was needed for study inclusion Besides clinical examination and visual acuity tests for far and near, fluorecscein angiographies and indocyanine green angiographies were performed in 3 months intervals and evaluated by two independent retinal specialists uninvolved in patients selection and the surgery. The occurrence of recurrent CNV either on fluorescein angiography or on indocyanine green angiography was evaluated. Results: 68 eyes (100%) of 66 patients could be included in this study. A recurrent extrafoveal membrane at the edge of the surgical area was found in 3 cases (4.4%). There was a medium observation time of 24 months (minimal 12 months - maximum 42 months). In one eye the membrane became fibrotic without treatment, two eyes received one laser- treatment each and became fibrotic thereafter. Final visual acuity was not influenced by this occurrence. Conclusion: These results suggest that transplantation of autologous RPE reduces the rate of recurrences after CNV removal.
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