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A.G. Robson, C.A. Egan, A.C. Bird, F.W. Fitzke, G.E. Holder; Multi-Focal ERG, Pattern ERG and Psychophysical Correlates of Fundus Autofluorescence Abnormalities in Patients With Retinitis Pigmentosa . Invest. Ophthalmol. Vis. Sci. 2003;44(13):535.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare the results of multi-focal and pattern electroretinography (mfERG, PERG), and fine matrix mapping in the examination of patients with retinitis pigmentosa (RP) and macular abnormalities present on fundus autofluorescence imaging. Methods: 10 patients with a clinical diagnosis of RP were selected according to 3 criteria: rod-cone dystrophy according to ISCEV-standard ERGs, visual acuity 6/9 or better, and an abnormal high density ring on fundus autofluorescence imaging (AF). AF imaging of lipofuscin at the level of the RPE was performed using a confocal scanning laser ophthalmoscope (modified Zeiss). Mf ERG, PERG and fine matrix mapping (FMM) were performed. Mf ERG was expressed numerically as the sum of mean amplitudes for the central response and 4 concentric retinal areas. Results: There was high correlation between PERG P50 component amplitude and the summed means of the mf ERG negative N1 component (r=0.78) and positive P1 component (r=0.72). The eccentricity at which the mf ERG P1 was reduced to <0.6µV showed high correlation with the radius of the ring of high density (r=0.64). Fine matrix mapping revealed a severe loss of sensitivity concordant with the spatial distribution of the AF ring. Conclusions: Both the mf ERG and PERG P50 amplitude suggested relative preservation of macular function within the AF ring, consistent with the sensitivity losses demonstrated by FMM.
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