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M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, H. Sattmann, M. Stur, T. Ko, O. Findl, J.G. Fujimoto, W. Drexler; Ultrahigh Resolution Optical Coherence Tomography In Macular Dystrophy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):538.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To examine and compare intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR-OCT) with reference to the intraretinal layers in the healthy macula. Methods: A compact, new generation UHR-OCT system has been developed and used in a clinical setting for the first time. 20 patients with Stargardt's disease (SD) (8 female and 12 male, mean age 35.8) and 20 patients with adult-onset foveomacular dystrophy (AOFVD) (10 female and 10 male, mean age 61.9) were imaged using UHR-OCT. Results: Patients with SD had a diffuse degenerative change with a reduction in all retinal layers, sub-pigmentepithelial deposits and focal loss of photoreceptors. Patients with AOFVD, on the other hand, had a normal retinal thickness, subretinal deposits and mostly intact photoreceptors. Conclusion: It has been demonstrated that UHR-OCT is a clinically feasible tool in examining and quantifying structural changes in hereditary macular dystrophy and therefore has the potential to contribute a better understanding of ocular pathogenesis.
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