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J. Hargitai, G. Somfai, R. Vámos, Á. Farkas, P. Gouras, G. Salacz; Foveal Thickness and Macular Volume Changes in Stargardt Macular Dystrophy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):544.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare foveolar thickness and macular volume in patients with Stargardt macular dystrophy and normal control subjects. Methods: 36 eyes of eighteen Hungarian patients (9 female, 9 male) suffering from Stargardt macular dystrophy aged 8-45 (mean:28) and 30 eyes of 15 age mached healthy individuals were tested with optical coherence tomography (OCT, Humphrey-Zeiss Instruments, USA ). Six 6mm long radial scans manually centered on the fovea were obtained in all eyes. Foveolar thickness (FT) and total macular volume (TMV) were measured automatically using the mapping software of OCT in the 9 Early Treatment Diabetic Retinopathy Study areas of 3500µm in diameter. Results: Patients with Stargardt macular dystrophy showed to have markedly thinned retina in the foveola, and decreased macular volume 65,4µm and 1.63mm3 respectively, compared to 166µm and 2.46mm3 in the normal subjects. We observed a linear correlation between visual acuity and macular volume in our patients with Stargardt macular dystrophy. Conclusion: Extensive foveolar thinning and macular volume loss can be observed in Stargardt macular dystrophy. Visual acuity might be related to macular volume, but a larger study is needed to confirm this.
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