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K.D. Rosenberg, T.G. Murray, A. Berrocal, E. Ysasaga, R. Loo, A. Aragon, M. Douglas, W. Feuer, G. Gregori; Continuous versus Non-continuous Laser Photocoagulation for the Treatment of Threshold Retinopathy of Prematurity . Invest. Ophthalmol. Vis. Sci. 2003;44(13):596.
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Purpose: To compare the efficacy of novel continuous laser photocoagulation with standard non-continuous laser photocoagulation in the treatment of threshold retinopathy of prematurity. Methods: An IRB-approved consecutive retrospective case series. Records of Bascom Palmer Eye Institute and Jackson Memorial Hospital were reviewed to identify patients with threshold retinopathy of prematurity who underwent laser treatment by our retina service between 1996-2002. We compared post-operative complications, the need for re-treatment and the rate of disease progression between the two treatment modalities. Patients were evaluated at 1 week, 1 month and 6 months post-treatment and at last follow-up. Results: There were 42 patients (84 eyes), 28 patients (56 eyes) underwent non-continuous photocoagulation and 14 patients (28 eyes) underwent continuous photocoagulation. There were 22 males and 20 females with no significant demographic differences between the two treatment groups. The mean overall birth weight was 689 grams (range 415-1200 grams) and the mean overall gestational age was 24.9 weeks (range 23-29 weeks). Post-operative complications occurred in 28 eyes (50%) of patients treated with non-continuous laser therapy and 8 eyes (29%) in patients treated with continuous laser therapy. Seven eyes (12.5%) treated with non-continuous laser photocoagulation required re-treatment versus none of the eyes treated with continuous laser photocoagulation (p=0.12). In the non-continuous group, 4 eyes (7%) progressed to more advanced disease (p=0.28), 3 eyes to stage 4a and 1 eye to stage 4b. No patients treated with continuous photocoagulation progressed to more advanced disease. No patients in either group progressed to stage 5 disease. Conclusions: Continuous laser photocoagulation is safe and effective and can be considered a treatment option for threshold retinopathy of prematurity. In addition, the use of continuous pattern photocoagulation as a treatment modality reduced the need for supplemental treatment and was associated with a decreased rate of disease progression.
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