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T. Takahashi, K. Sugiyama, K. Kawase, K. Miyake, T. Yamamoto, Y. Kitazawa; Probability of Detecting Disk Hemorrhages Over Time in Glaucoma Before and After Trabeculectomy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):83.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the effect of marked reduction of intraocular pressure (IOP) by trabeculectomy on frequency of disk hemorrhages in primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG). Methods: We retrospectively studied 404 eyes of 265 patients with POAG, and 164 eyes of 115 patients with NTG. These patients were followed regularly at 1- to 3-month interval (mean: 1.5 months) at the Glaucoma Service of Gifu University Hospital before and after trabeculectomy with mitomycin C or 5-fluorouracil. We applied a Kaplan-Meier life-table analysis of survival data regarding non-detection of disk hemorrhages before and after trabeculectomy.Results: Trabeculectomy significantly reduced IOP (POAG:20.1±4.9to11.8±5.9mmHg; NTG:15.2±1.7 to11.8±5.9mmHg:mean±SD). The life-table analysis revealed that the final cumulative probability of detecting a disk hemorrhage after surgery was calculated to be 3.9±1.1% (calculated probability±standard error) and was significantly lower than that (30.7±4.9%) before surgery in POAG (P<0.001). Likewise, in NTG, the final probability after surgery was 12.8±3.1% and was significantly lower than that (49.6±12.1%) before surger (P<0.001).Conclusions: The marked reduction of IOP by trabeculectomy significantly reduces frequency of disk hemorrhages.
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