May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Neural Losses Correlated With Visual Losses in Clinical Perimetry
Author Affiliations & Notes
  • R.S. Harwerth
    College of Optometry, University of Houston, Houston, TX, United States
  • L. Carter-Dawson
    Department of Ophthalmology and Visual Science, University of Texas - Houston, Houston, TX, United States
  • E.L. Smith III
    Department of Ophthalmology and Visual Science, University of Texas - Houston, Houston, TX, United States
  • M.L. Crawford
    Department of Ophthalmology and Visual Science, University of Texas - Houston, Houston, TX, United States
  • G. Barnes
    Department of Pharmacology, Alcon Research, Ltd, Fort Worth, TX, United States
  • Footnotes
    Commercial Relationships  R.S. Harwerth, None; L. Carter-Dawson, None; E.L. Smith III, None; M.L.J. Crawford, None; G. Barnes, None.
  • Footnotes
    Support  Alcon Research, Ltd., NEI grants P30 EY07751, P30 EY10608, R01 EY11545
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1040. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R.S. Harwerth, L. Carter-Dawson, E.L. Smith III, M.L. Crawford, G. Barnes; Neural Losses Correlated With Visual Losses in Clinical Perimetry . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1040.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: The validity of clinical perimetry for evaluation of the pathology of glaucoma is based on correlated losses in retinal ganglion cells and visual sensitivity, but relationships between neural and visual losses are not precise. The purpose of the present study was to investigate the sources of imprecision in the neural-sensitivity relationship for standard clinical perimetry. Methods: Perimetry data, by behavioral testing, and retinal histology data were obtained from rhesus monkeys with significant visual field defects caused by experimental glaucoma. Ganglion cell densities were obtained from sections of retina that corresponded to perimetry test locations at 3x3 deg, 9x9 deg and 15x15 deg in each quadrant and at 4 additional nasal field locations. Perimetry sensitivity as a function of ganglion cell density at corresponding retina/visual field locations was analyzed. Results: In log-log coordinates, the relationship for visual sensitivity as a function of ganglion cell density was linear. Neural-sensitivity functions were unsystematic across subjects and the neural and sensitivity losses were often poorly correlated for a given subject. The imprecision of the general relationship was reduced by compensation for the effect of retinal eccentricity on the slope and intercept of the neural-sensitivity relationship, and for the variation in retinal ganglion cell density with eccentricity. Conclusions: With retinal eccentricity as a factor, the neural losses from glaucoma are predictable from visual sensitivity measurements by clinical perimetry. The relationships derived from experimental glaucoma in monkeys also accurately predict the rate of age-related losses of retinal ganglion cells in humans, based on the normative perimetry data for age-related reductions in visual sensitivity.

Keywords: perimetry • ganglion cells • animal model 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×