May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Association of 5,10-Methylenetetrahydrofolate Reductase Gene Polymorphism with Normal-tension Glaucoma
Author Affiliations & Notes
  • S. Woo
    Ophthalmology, Seoul Nat'l Univ Hosp, Seoul, Republic of Korea
  • J. Kim
    Laboratory Medicine, Seoul Nat'l Univ Hosp,Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • D. Kim
    Ophthalmology, Seoul Nat'l Univ Hosp, Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • S. Park
    Ophthalmology, Seoul Nat'l Univ Hosp, Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • H. Ko
    Ophthalmology, Seoul Nat'l Univ Hosp, Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • T. Yoo
    Family Medicine, Seoul Nat'l Univ Hosp, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  S. Woo, None; J. Kim, None; D. Kim, None; S. Park, None; H. Ko, None; T. Yoo, None.
  • Footnotes
    Support  04-2002-038 from the Seoul National University Hospital Research Fund.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1113. doi:
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      S. Woo, J. Kim, D. Kim, S. Park, H. Ko, T. Yoo; Association of 5,10-Methylenetetrahydrofolate Reductase Gene Polymorphism with Normal-tension Glaucoma . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1113.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To compare the frequency of polymorphism of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene between patients with normal-tension glaucoma (NTG) and healthy subjects. Methods: Thirty-seven NTG patients and 42 healthy subjects without systemic vascular diseases including hypertension and diabetes were enrolled. DNA from peripheral blood lymphocytes was extracted and the genotype of polymorphism (C677T) in the MTHFR gene was determined using PCR followed by HinfI digestion. The frequencies of the polymorphic genotypes in patients with NTG and healthy subjects were compared using the chi-square test. Results: The frequencies of the three genotypes of the MTHFR gene in NTG patients (n = 37) were determined to be as follows; the TT genotype was found in 13 patients (35.1%), the CT genotype in 14 (37.8%) and the CC genotype in 10 (27.0%). In healthy subjects (n = 42), the TT genotype was found in 6 (14.3%), the CT genotype in 21 (50.0%) and the CC genotype in 15 (35.7%). The TT genotype was found to be significantly more frequent in the NTG patients than in the healthy subjects (p =0.030, odds ratio of 3.3, 95% C.I. = 1.1 - 9.7). Conclusions: The TT genotype of the MTHFR gene was found to be significantly associated with NTG, which suggests that vascular pathology might play a role in the pathogenesis of NTG.

Keywords: genetics 
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