May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Comparison between Surgical and Medical Treatment Effect on Diurnal Intraocular Pressure Fluctuations in Open Angle Glaucoma Patients
Author Affiliations & Notes
  • G. Manni
    Department of Ophthalmology, Univ of Rome - Tor Vergata, Rome, Italy
  • R. Migliardi
    Department of Ophthalmology, Univ of Rome - Tor Vergata, Rome, Italy
  • D. Lorenzano
    Department of Ophthalmology, Univ of Rome - Tor Vergata, Rome, Italy
  • S. Minchiotti
    Department of Ophthalmology, Univ of Rome - Tor Vergata, Rome, Italy
  • M.G. Bucci
    Department of Ophthalmology, Univ of Rome - Tor Vergata, Rome, Italy
  • Footnotes
    Commercial Relationships  G. Manni, None; R. Migliardi, None; D. Lorenzano, None; S. Minchiotti, None; M.G. Bucci, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1191. doi:
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      G. Manni, R. Migliardi, D. Lorenzano, S. Minchiotti, M.G. Bucci; Comparison between Surgical and Medical Treatment Effect on Diurnal Intraocular Pressure Fluctuations in Open Angle Glaucoma Patients . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1191.

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Abstract

Abstract: : Purpose: The aim of the study is to evaluate the effect of trabeculectomy on the IOP fluctuations within a day compared to non-selective ß-blockers and latanoprost therapy respectively. Methods: A prospective unmasked study was conducted on 24 patients with POAG. Eight eyes underwent trabeculectomy (group 1) since at least three months, 8 eyes were ongoing non-selective beta-blockers twice a day (group 2) and 8 eyes were on latanoprost (group 3). Primary trabeculectomy was performed by the same surgeon without using any antimetabolite, the medical treatment was unchanged for at least 3 months. The study-eye was randomly included with the exception of patients who underwent trabeculectomy because only one eye was eligible for the study. In each eye the IOP was measured by applanation tonometry (Goldmann) every two hours from 8 AM to 8 PM by the same physician. Descriptive statistic was used for each curve; standard deviation, coefficient of variation and range of different treatment were compared by unpaired t-test. Results: Results are shown in the table: The SD and range were significantly lower in group 1 compared to group 2 (p=0.03, p=0.01 respectively) and 3 (p=0.03, p=0,02 respectively). For the same parameters there was no statistically significant difference between group 2 and 3 (p=0,92, p=0,64). Conclusions: Trabeculectomy seems to be more effective in stabilizing the IOP during the day compared to non-selective ß-blockers and prostaglandins.  

Keywords: intraocular pressure • circadian rhythms 
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