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G. Manni, R. Migliardi, D. Lorenzano, S. Minchiotti, M.G. Bucci; Comparison between Surgical and Medical Treatment Effect on Diurnal Intraocular Pressure Fluctuations in Open Angle Glaucoma Patients . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1191.
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Purpose: The aim of the study is to evaluate the effect of trabeculectomy on the IOP fluctuations within a day compared to non-selective ß-blockers and latanoprost therapy respectively. Methods: A prospective unmasked study was conducted on 24 patients with POAG. Eight eyes underwent trabeculectomy (group 1) since at least three months, 8 eyes were ongoing non-selective beta-blockers twice a day (group 2) and 8 eyes were on latanoprost (group 3). Primary trabeculectomy was performed by the same surgeon without using any antimetabolite, the medical treatment was unchanged for at least 3 months. The study-eye was randomly included with the exception of patients who underwent trabeculectomy because only one eye was eligible for the study. In each eye the IOP was measured by applanation tonometry (Goldmann) every two hours from 8 AM to 8 PM by the same physician. Descriptive statistic was used for each curve; standard deviation, coefficient of variation and range of different treatment were compared by unpaired t-test. Results: Results are shown in the table: The SD and range were significantly lower in group 1 compared to group 2 (p=0.03, p=0.01 respectively) and 3 (p=0.03, p=0,02 respectively). For the same parameters there was no statistically significant difference between group 2 and 3 (p=0,92, p=0,64). Conclusions: Trabeculectomy seems to be more effective in stabilizing the IOP during the day compared to non-selective ß-blockers and prostaglandins. View OriginalDownload SlideView OriginalDownload Slide
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