May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Matrix Metalloproteinases (MMPs) Concentration in Tears of Eyes with Filtering Blebs
Author Affiliations & Notes
  • N. Mathalone
    Ophthalmology, Carmel Medical Center, Haifa, Israel
  • M.A. Rahat
    Serology Laboratory, Carmel Medical Center, Haifa, Israel
  • N. Lahat
    Serology Laboratory, Carmel Medical Center, Haifa, Israel
  • O. Geyer
    Serology Laboratory, Carmel Medical Center, Haifa, Israel
  • Footnotes
    Commercial Relationships  N. Mathalone, None; M.A. Rahat, None; N. Lahat, None; O. Geyer, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1205. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      N. Mathalone, M.A. Rahat, N. Lahat, O. Geyer; Matrix Metalloproteinases (MMPs) Concentration in Tears of Eyes with Filtering Blebs . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1205.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: Thin cystic blebs complicate filtration surgery as they are more susceptable to leakage and hypotony. Therefore the pevention of bleb growth is important. Since matrix metalloproteinases (MMPs) are known to play an essential role in connective tissue remodeling and wound healing, MMPs might also be involved in bleb formation. The aim of our study was to determine whether an enhanced MMP-9 and MMP-2 secretion could be found in tear film of eyes with cystic blebs. Methods: Unstimulated tear fluid was collected from glaucoma patients with cystic (n=12) and flat (n=10) filtering blebs and from age matched normal controls (n=17). Levels of MMP-2 and MMP-9 were determined by gelatin zymography. Results: Active MMP-2 concentrations were detected in a significantly higher (P0.05). Conclusions:In our study, eyes with cystic blebs showed abnormally high levels of the active form of MMP-2 in the tear fluid. This suggests that MMPs may have a role in the development and healing of filtering blebs.

Keywords: enzymes/enzyme inhibitors • wound healing 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×