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K. Mohaseb, M. Linder, P. Dolman, G.E. Wilkins, J. Rootman; Validation of a Screening Rule for Thyroid Orbitopathy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):768.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To validate a screening tool for the early identification of thyroid orbitopathy. Methods: The self-reporting symptomatology questionnaire called the Thyroid Orbitopathy Indicator was administered along with a standard ophthalmic examination to patients newly diagnosed with Grave's hyperthyroidism. The patients were initially diagnosed by endocrinologists and asked to take part in the study. The questionnaire and its resulting rule (Vancouver Orbitopathy Rule) were then compared to the ophthalmic examination to determine the efficacy of the screening rule in diagnosis of thyroid orbitopathy. Results: Through analysis of 49 patients, the Vancouver Orbitopathy Rule was found to have a sensitivity of 0.82 and specificity of 0.75. The instrument's positive predictive value was 0.64 and its negative predictive value was 0.89. Conclusions: The Vancouver Orbitopathy Rule is a useful screening tool in the early diagnosis of thyroid orbitopathy.
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