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A.A. Fawzi, B. Vo, C. Cha, R. Kriwanek, A. Carts, H. Ramkumar, J.R. Heckenlively, R.Y. Foos, B.J. Glasgow; Asteroid Hyalosis in an Autopsy Population: The UCLA Experience . Invest. Ophthalmol. Vis. Sci. 2003;44(13):779.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To study the prevalence and correlates of asteroid hyalosis (AH) in autopsy eyes studied at the Jules Stein Eye Institute, UCLA. Methods: Retrospective review of the UCLA autopsy eye database in the period from 1965 to 2000 yielded 10801 patients. The patients' medical histories were reviewed for evidence of hypertension, hyperlipidemia, alcohol abuse, hypercalcemia, hypothyroidism, and chronic renal failure, as well as autopsy evidence of optic atrophy, glaucoma, macular degeneration, posterior vitreous detachment, atherosclerosis, liver and renal diseases. AH was diagnosed by examination of the autopsy eyes. Univariate and multivariate statistical methods were used to analyse our data. Results: AH was present in 1.99% of patients. Patients ranged in age from 0 (still birth) to 109 years. 545 patients were included in the 81-90 year age group, and 74 patients were over 90 years of age. 62.26% of patients were males. The racial distribution included 75% Causcasians, 13% African-Americans, 2% Asians, and 10% others. Significant correlations on chi-square analysis were found for age (p<0.0001), male gender (p=0.01), macular degeneration (p=0.02), hypertension (p=0.04) and atherosclerosis (p<0.0001). After adjusting for age on a multivariate logistic regression analysis, there was no statistical significance found for any of these factors. Specifically, no statistically significant association was found with Diabetes Mellitus or alcohol abuse whether on univariate or multivariate analysis. Analysis of the odds ratio showed a strong age effect that increased from 3.73 (95% Wald CI 1.76,7.9) in age group 41-50, compared to 19.96 (95% Wald CI 6.8,58.2) in the age group of patients over 90. Conclusions: A unique epidemiologic autopsy cohort study of AH and its systemic associations yielded a higher prevalence of AH than previous studies. AH was strongly correlated with age. Unlike some previous reports, we found no statistically significant correlation between AH and Diabetes Mellitus.
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