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H.A. Reitsamer, J.W. Kiel; Ciliary Oxygen Tension, Ciliary Blood Flow and Brimonidine . Invest. Ophthalmol. Vis. Sci. 2003;44(13):959.
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Purpose: To measure oxygen tension (PO2) and blood flow (CBF)in the ciliary body simultaneously and to investigate the effectof brimonidine on these two parameters. Methods: All experimentswere performed in anesthetized new Zealand white rabbits (n=7).For measurements of oxygen tension, oxygen sensitive microelectrodeswere advanced through a scleral window and placed in the vicinityof the ciliary body. CBF was measured by laser Doppler flowmetry,intraocular pressure (IOP) was measured via direct cannulationof the vitreous and mean arterial pressure (MAP) was measuredthrough a catheter in the ear artery. Brimonidine was appliedtopically on the cornea (40 µl, 0.15 %) Results: View OriginalDownload SlideView OriginalDownload Slide Brimonidine lowered IOP, CBF andPO2 significantly, however, no significant effect on MAP wasobserved. Conclusions: It is possible to measure ciliary PO2and ciliary blood flow simultaneously in this rabbit model.Despite the increase in perfusion pressure (MAP-IOP), CBF wasdecreased by brimonidine which indicates it is a potent vasoconstrictorin the ciliary circulation. In addition, it reduces PO2 measuredin the vicinity of the ciliary processes. Baseline changes View OriginalDownload SlideView OriginalDownload Slide
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