May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Retinal Venous Oxygen Saturation Unaltered With Age
Author Affiliations & Notes
  • R.V. Kumar
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • A. Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • L. Kagemann
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • S.P. Kresovsky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • R. Dinn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • E. Rechtman
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • A. Yee
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States
  • Footnotes
    Commercial Relationships  R.V. Kumar, None; A. Harris, None; L. Kagemann, None; S.P. Kresovsky, None; R. Dinn, None; E. Rechtman, None; A. Yee, None.
  • Footnotes
    Support  Acknowledgment: unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1299. doi:
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      R.V. Kumar, A. Harris, L. Kagemann, S.P. Kresovsky, R. Dinn, E. Rechtman, A. Yee; Retinal Venous Oxygen Saturation Unaltered With Age . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1299.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To examine the effect of age on retinal venous blood oxygen saturation and retinal oxygen extraction under normoxic and hypoxic conditions. Methods: All procedures were approved by an IRB, and informed consent obtained. Thirty-two oximetry images were obtained in 14 normal healthy adults (24 -52 years, mean 32, SD 8; 12 male, 20 female, 8 smoker, and 24 non-smoker), retinal artery and vein blood oxygen saturation (O2sat) was measured by a newly developed digital retinal oximeter while breathing room air, and a mixture of room air and nitrogen. During hypoxia, arterial saturations were reduced to approximately 90%. Oxygen extraction was calculated as arterial O2sat – venous O2sat. Venous O2sat and retinal oxygen extraction were compared to age by linear regression analysis, with p < 0.05 considered significant. Results: There was no significant correlation between age and retinal oxygen dynamics. The insensitivity of retinal oxygen delivery to age was consistent regardless of sex or smoking status. Conclusions: While breathing room air, and in response to hypoxia, venous O2sat and retinal extraction of oxygen remain consistent throughout adult life in healthy eyes.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, S • retina • hypoxia 
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