May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Variation in Retinal Venous Blood Saturation During Hypoxia Between Smokers and Non-Smokers
Author Affiliations & Notes
  • B.A. Siesky
    Biology, Physiology, Indiana Univ Sch Med/Ophthalmolo, Indianapolis, IN, United States
  • A. Harris
    Biology, Physiology, Indiana Univ Sch Med/Ophthalmolo, Indianapolis, IN, United States
  • L. Kagemann
    Biology, Physiology, Indiana Univ Sch Med/Ophthalmolo, Indianapolis, IN, United States
  • S.P. Kresovsky
    Biology, Physiology, Indiana Univ Sch Med/Ophthalmolo, Indianapolis, IN, United States
  • R.B. Dinn
    Biology, Physiology, Indiana Univ Sch Med/Ophthalmolo, Indianapolis, IN, United States
  • Footnotes
    Commercial Relationships  B.A. Siesky, None; A. Harris, None; L. Kagemann, None; S.P. Kresovsky, None; R.B. Dinn, None.
  • Footnotes
    Support  Unrestricted grant Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1303. doi:
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    • Get Citation

      B.A. Siesky, A. Harris, L. Kagemann, S.P. Kresovsky, R.B. Dinn; Variation in Retinal Venous Blood Saturation During Hypoxia Between Smokers and Non-Smokers . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1303.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To compare changes in venous blood saturation during hypoxia between smokers and non-smokers. Methods: : All procedures were approved by an IRB, and informed consent obtained. Thirty-two oximetry images (12 male, 20 female, 8 smoker, and 24 non-smoker) were obtained in 14 normal healthy adults (mean 37.1 years, SD=9.1) using a newly developed digital retinal oximeter. Measurements were taken while subjects were breathing room air and a mixture of room air and nitrogen. During hypoxia, arterial saturations were reduced to approximately 90%. Images were analyzed to determine arterial and venous oxygen saturation. The levels of venous oxygen saturation during normal oxygen and hypoxic conditions were compared using a Mann-Whitney unpaired u test for the smoking and non-smoking groups. A p>0.05 was considered significant. Results: Hypoxia reduced venous oxygen saturation in the non-smoker group (p = 0.0099) however the reduction in the smoking group was not significant (p = 0.65). There was no significant difference in venous O2sat between smokers and non-smokers. Conclusions: Smokers present with an altered retinal oximetric response to hypoxia.

Keywords: imaging/image analysis: non-clinical 
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