May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Visual Acuity Loss in Keratoconus
Author Affiliations & Notes
  • K. Zadnik
    College of Optometry, Ohio State University, Columbus, OH, United States
  • K.B. Schechtman
    Division of Biostatistics, Washington University, St. Louis, MO, United States
  • B.A. Wilson
    Department of Ophthalmology & Visual Sciences, Washington University, St. Louis, MO, United States
  • J.T. Barr
    Department of Ophthalmology & Visual Sciences, Washington University, St. Louis, MO, United States
  • T.B. Edrington
    Southern California College of Optometry, Fullerton, CA, United States
  • T.T. McMahon
    Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States
  • D.F. Everett
    National Eye Institute, Bethesda, MD, United States
  • M.O. Gordon
    National Eye Institute, Bethesda, MD, United States
  • CLEK Study Group
    National Eye Institute, Bethesda, MD, United States
  • Footnotes
    Commercial Relationships  K. Zadnik, None; K.B. Schechtman, None; B.A. Wilson, None; J.T. Barr, None; T.B. Edrington, None; T.T. McMahon, None; D.F. Everett, None; M.O. Gordon, None.
  • Footnotes
    Support  EY10419, EY10069, EY10077, EY 12656, EY02687, Conforma, Paragon, CIBA, Wildermuth Foundation
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1308. doi:
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      K. Zadnik, K.B. Schechtman, B.A. Wilson, J.T. Barr, T.B. Edrington, T.T. McMahon, D.F. Everett, M.O. Gordon, CLEK Study Group; Visual Acuity Loss in Keratoconus . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1308.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study is an observational study of more than 1200 keratoconus patients. We sought to determine the percentage of eyes that lost 10 letters or more of visual acuity (VA) over 4 years of follow-up and to examine the association of baseline factors with this acuity loss. Methods: We identified eyes that lost 10 letters or more of high contrast habitual visual acuity or low contrast visual habitual acuity after 4 years of follow-up. We report univariate analyses (percentages, means, standard deviations) of baseline factors for eyes that did and did not lose 10 letters or more of habitual visual acuity. Results: Thirteen percent (269 of 2064 eyes) lost 10 letters or more in high contrast habitual visual acuity, and 16.7% (344 of 2,062 eyes) lost 10 letters or more in low contrast habitual visual acuity. Conclusions: Clinically significant loss of visual acuity (10 letters or more) was observed in 13-17% of eyes in 4 years. In univariate analyses, baseline factors that were associated with this loss of acuity included female gender, corneal scarring, contact lens wear, steeper corneal curvature, and worse initial acuity. Baseline values for eyes that lost 10 letters or more of visual acuity compared to eyes that did not  

Keywords: keratoconus • cornea: clinical science • contact lens 
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