May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Videokeratographic Anomalies in Familial Keratoconus
Author Affiliations & Notes
  • F.J. Malecaze
    Ophthalmology, CHU, Toulouse, France
  • D. Levy
    Ophthalmology, CHU, Toulouse, France
  • H. Hutchings
    Ophthalmology, INSERM U 563, Toulouse, France
  • J. Guell
    Ophthalmology, IMO, Barcelona, Spain
  • C. Burillon
    Ophthalmology, IMO, Barcelona, Spain
  • J. Colin
    Ophthalmology, IMO, Barcelona, Spain
  • J. Rouland
    Ophthalmology, IMO, Barcelona, Spain
  • J. Arné
    Ophthalmology, IMO, Barcelona, Spain
  • L. Laroche
    Ophthalmology, Hopital XV XX, Paris, France
  • Footnotes
    Commercial Relationships  F.J. Malecaze, None; D. Levy, None; H. Hutchings, None; J. Guell, None; C. Burillon, None; J. Colin, None; J. Rouland, None; J. Arné, None; L. Laroche, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1316. doi:
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    • Get Citation

      F.J. Malecaze, D. Levy, H. Hutchings, J. Guell, C. Burillon, J. Colin, J. Rouland, J. Arné, L. Laroche; Videokeratographic Anomalies in Familial Keratoconus . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1316.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:Detection of low expressivity forms of keratoconus among relatives of familial keratoconus patients. Methods: A multicentric prevalence study was conducted. The study included 23 families with 55 clinical keratoconus, 89 first degree relatives, 43 other relatives and a control group of 130 subjects. Qualitative and quantitative analysis of corneal shape was performed by videokeratoscopy using a 0.5 diopter increment scale. Videokeratoscopic indices were calculated (K, AST, Srax, I-S and Kisa%) and corneal shapes were sorted according to the Bogan/Rabinowitz classification (Bogan et al., Arch. Ophthalmol., 1990, 108(7):945-9). Statistical comparisons were conducted between first degree relatives and other relatives and a control population. Results: A new corneal pattern was observed: Jinv (a mirror image of the previously described J shape). J and Jinv shapes were over-represented in the relatives of familial keratoconus patients and quantitative analysis revealed that I-S, Srax and Kisa% values were significantly higher for these suspect patterns. Conclusions: Topographic examination of keratoconus families allowed us to detect suspect videokeratoscopic patterns and provides new data for the detection of forme fruste keratoconus wich is a major contraindication for corneal refractive surgery.

Keywords: keratoconus • topography • genetics 
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