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S. Thota, W.L. Miller, A. Minavi, J. Jackson, N. Leach, J. Bergmanson; Corneal Thickness and Sensitivity in Keratoconic Subjects . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1317.
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Purpose: The relationship of corneal sensitivity and thickness measurements of established gas permeable keratoconic subjects was evaluated in this study. Methods: Corneal measurements were taken on both eyes of nine keratoconic subjects (Age range 21-38; average 30). Corneal sensitivity was determined immediately after lens removal by a slit-lamp mounted Cochet-Bonnet aesthesiometer. Three consecutive measurements from the central and inferior mid-peripheral cornea were averaged. Using an OrbScan topographer, pachymetry readings were collected from six different locations on the cornea. Results: Mean central sensitivity was 3.98mm and 4.02mm; mean peripheral sensitivity was 4.83mm and 4.93mm right and left eyes respectively. However, there was no statistical difference between central and peripheral corneal sensitivities in either eye (paired t-test, two-tailed). Sensitivity of the right and left central corneas showed a mild correlation with the cone thickness of the right and left eyes respectively. Conclusions: The peripheral cornea showed a slightly greater corneal sensitivity compared to the central cornea. However, the central corneal sensitivity data showed a greater variance when compared to the peripheral cornea. The majority of subjects exhibited an inferior cone, which may help to explain the increased sensitivity in the peripheral cornea. Data suggests a lack of correlation between peripheral corneal sensitivity and cone thickness, but supports a correlation between central corneal sensitivity and cone thickness of keratoconic patients.
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