May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Detection of Connective Tissue Growth Factor (CTGF) in Pterygium
Author Affiliations & Notes
  • G.B. van Setten
    Ophthalmology, Karolinska Inst/St Eriks Eye, Stockholm, Sweden
  • M. Aspiotis
    Ophthalmology, University of Ioannina, Ioannina, Greece
  • T.D. Blalock
    Institute of Wound Research, University of Florida, Gainesville, FL, United States
  • G. Grotendorst
    Cell Biology and Anatomy, University of Miami, School of Medicine, Miami, FL, United States
  • G.S. Schultz
    Cell Biology and Anatomy, University of Miami, School of Medicine, Miami, FL, United States
  • Footnotes
    Commercial Relationships  G.B. van Setten, None; M. Aspiotis, None; T.D. Blalock, None; G. Grotendorst, None; G.S. Schultz, None.
  • Footnotes
    Support  EY05587
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1325. doi:
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      G.B. van Setten, M. Aspiotis, T.D. Blalock, G. Grotendorst, G.S. Schultz; Detection of Connective Tissue Growth Factor (CTGF) in Pterygium . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1325.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To investigate the presence of CTGF in pterygia and its localization in relation to vascular endothelial growth factor (VEGF). Methods: Samples pterygia were collected during surgery with informed consent of 20 patients. Specific antibodies against CTGF were used to detect CTGF using immuno-histochemistry. The same specimes were stained with commercial antibodies for VEGF. Results: Intense staining for CTGF was detected in the epithelium of all samples of pterygium. Even some stromal keratocytes expresed CTGF. Also VEGF was detected in all samples but staining pattern differed slightly. The control sections were negative. Conclusions: It was shown that CTGF is present in the epithelium of pterygia whereas is appears to be absent in normal conjunctiva. The expression of CTGF in pathological conditions may indicate a contribution of this growth factor to th pathology of pterygium by its involvement in fibrosis. The simultaneous presence with VEGF suggests growth factor interaction the details of which need to be clarified.

Keywords: cornea: clinical science • Pterygium • pathology: human 
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