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K. Surti, R.L. Hurwitz, M.Y. Hurwitz, P. Chevez-Barrios; Matrix Metalloproteinases in Retinoblastoma: Correlation with Metastatic Behavior . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1421.
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Purpose: To detect the expression pattern of MMPs in invasive and noninvasive human retinoblastoma and to evaluate a potential correlation with the metastatic potential of the tumor. Methods: Formalin fixed, paraffin embedded enucleated eyes were collected from eight patients with retinoblastoma, four with invasive retinoblastoma involving the optic nerve or the choroid and four with noninvasive retinoblastoma. Immunohistochemical staining of MMP-1, MMP-2, and MMP-9 was performed. Results: All four of the invasive tumors examined stained positively for MMP-1 and MMP-2 and two of the four stained positively for MMP-9. In contrast, none of the four non-invasive tumors examined stained positively for either MMP-1 or MMP-9 and only one of the four stained positively for MMP-2. Conclusions: The results suggest that MMP expression correlates positively with the invasive behavior of retinoblastoma. Matrix metalloproteinases may therefore be potential therapeutic targets for the treatment or prevention of metastatic retinoblastoma.
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