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H.L. Karageozian, A. Climent, J. Parks, L. Llamas, G. Cuevas, V. Garcia, F. Garnica, V. Robredo, O. Schnider; Determine the Effectiveness of a New Broad Spectrum Ophthalmic Anti-infective Solution in Treating Pseudomonas Aeruginosa Keratitis in Albino Rabbits . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1453.
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Objective: To evaluate the effectiveness of a new broad spectrum Ophthalmic anti-infective solution "Oxyd" in a prospective, randomized, masked and placebo control study, furthermore compare the activity of "Oxyd" to Ofloxacin Ophthalmic solution, combination of Ofloxacin and "Oxyd" and placebo control in a rabbit corneal ulcer model induced by human resistant strain of Pseudomonas aeruginosa. Materials and Methods: Pseudomonas aeruginosa keratitis was induced in the right eye of 72 New Zealand Albino rabbits by scrapping the corneal epithelium, and applying 50,000 cfu of viable P. aeruginosa. After 24 hours the rabbits were examined and a second dose of 50,000 cfu viable p.aeruginosa was reapplied. The rabbits were randomized and divided into four groups of 18 rabbits each. GroupI received Ofloxacin drops, GroupII "oxyd" drops, GroupIII received combination of Ofloxacin and "Oxyd" and Group IV were placebo controls. The rabbits were examined on days 2, 4, and 7, and 6 rabbits from each group were randomly chosen and sacrificed; an 8 mm corneal disc was removed from the enucleated eyes, homogenized and plated for quantitative microbiological analysis. Results: Control of P.aeruginosa keratitis was achieved by Ofloxacin, "Oxyd", and Ofloxacin "Oxyd" combination treatments at 2, 4, and 7 days. However the Ofloxacin "Oxyd" combination treatment results were statistically significantly better than Ofloxacin alone or "Oxyd" alone treatments Conclusion: We conclude that the activity of "Oxyd" is similar to Ofloxacin in treating P. aeruginosa keratitis. The combination of Ofloxacin and "Oxyd" further enhances the effectiveness of the treatment for P.aeruginosa keratitis.
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