May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Kinetics of Killing of Ocular Isolates of Staphylococcus aureus and Staphylococcus epidermidis by Moxifloxacin
Author Affiliations & Notes
  • D.W. Stroman
    R&D Microbiology, Alcon Research, Ltd., Fort Worth, TX, United States
  • B. Medoza
    R&D Microbiology, Alcon Research, Ltd., Fort Worth, TX, United States
  • P. Sukplang
    R&D Microbiology, Alcon Research, Ltd., Fort Worth, TX, United States
  • R. Berry
    R&D Microbiology, Alcon Research, Ltd., Fort Worth, TX, United States
  • B.A. Schlech
    R&D Microbiology, Alcon Research, Ltd., Fort Worth, TX, United States
  • Footnotes
    Commercial Relationships  D.W. Stroman, Alcon E; B. Medoza, Alcon E; P. Sukplang, Alcon E; R. Berry, Alcon E; B.A. Schlech, Alcon E.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1463. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      D.W. Stroman, B. Medoza, P. Sukplang, R. Berry, B.A. Schlech; Kinetics of Killing of Ocular Isolates of Staphylococcus aureus and Staphylococcus epidermidis by Moxifloxacin . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1463.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose:The Gram-positive staphylococci are the most frequently recovered bacteria from superficial ocular infections. Moxifloxacin is a fourth-generation fluoroquinolone antibiotic with superior activity against Staphylococcus aureus and Staphylococcus epidermidis . The purpose of this study was to define the kinetics of kill of moxifloxacin against ocular isolates of S. aureus and S. epidermidis. Methods:The kinetics of kill was measured in vitro by the reduction in CFU/ml as a function of time at 35°C. The two ocular staphylococcal isolates were susceptible to moxifloxacin and other quinolone antibiotics. Moxifloxacin was tested at two concentrations, 50 and 500 µg/mL. Results:At 50 µg/mL, moxifloxacin killed 3 logs (99.9%) of S. aureus in 30 minutes and 4 logs (99.99%) in 120 minutes. At the higher concentration level [500µg/mL] moxifloxacin killed 3 logs in 45 minutes and 4 logs in 180 minutes. Against S. epidermidis, moxifloxacin killed 3 logs in 50 minutes at 50 µg/mL and 4 logs in 180 minutes. Moxifloxacin at 500 µg/mL killed 3 logs in 85 minutes and 4 logs in 180 minutes. Conclusions: These in vitro kinetics of kill studies demonstrate that moxifloxacin rapidly kills two important Gram-positive bacterial pathogens, Staphylococcus aureus and Staphylococcus epidermidis . The speed of kill observed for moxifloxacin is faster than that for second-generation quinolones under the same test conditions.

Keywords: antibiotics/antifungals/antiparasitics • microbial pathogenesis: experimental studies • Staphylococcus 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×