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R. Belfort, A.L. Höfling-Lima, B.C. Branco, L.B. Sousa, D. Freitas, M.C. Yu; In vitro Antibiotic Susceptibility of Ocular Isolates to Moxifloxacin, Gatifloxacin and Other Fluoroquinolones, São Paulo, Brazil . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1468.
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Purpose:To assess the in-vitro susceptibility of conjunctival and corneal bacterial isolates from 154 patients to Moxifloxacin, Gatifloxacin, Ciprofloxacin and Ofloxacin. Methods: Fluoroquinolones disc diffusion antibiotic susceptibilities tests were performed for Staphylococcus coagulase negative (SCN), Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus viridans isolated from cornea and conjunctiva, and Pseudomonas aeruginosa from corneal samples. Results: Corneal isolates S. aureus, S. viridans and S. pneumoniae antibiotic susceptibilities were the same for all quinolones (100%). For SCN and Pseudomonas aeruginosa antibiotic susceptibility for Ciprofloxacin was 86% and 87% respectively and for Ofloxacin was 81 and 87% respectively. All corneal isolates were susceptible to Moxifloxacin and Gatifloxacin. The conjunctival isolated S. pneumoniae were susceptible to all quinolones. Ciprofloxacin had 90% and Ofloxacin 94% of efficacy against SCN isolates. S. aureus were 100% susceptible to Ciprofloxacin and Ofloxacin. S. viridans were 25% susceptible to Ciprofloxacin and 75% to Ofloxacin. All SCN, S. aureus and S. pneumoniae isolated from the conjunctiva were susceptible to Moxifloxacin. All SCN, S. aureus and S. pneumoniae as well as 75% of the S. viridans isolated from the conjunctiva were susceptible to Gatifloxacin. Conclusions: In this naive population to systemic or local Moxifloxacin and Gatifloxacin these antibiotics have shown better in vitro efficacy than previous generations fluoroquilonones. S. viridans resistance to Gatifloxacin was observed from conjunctival samples. Clinical correlation studies are under way to better understand its clinical significance.
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