May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Sectorial Fundus Albipunctatus Is Not Associated With RDH5 Gene Mutation
Author Affiliations & Notes
  • Y. Hotta
    Department of Ophthalmology, Hamamatsu Univ Sch of Med, Hamamatsu, Japan
  • N. Tomita
    Department of Ophthalmology, Hamamatsu Univ Sch of Med, Hamamatsu, Japan
  • K. Koide
    Department of Ophthalmology, Hamamatsu Univ Sch of Med, Hamamatsu, Japan
  • T. Tsuchiya
    Department of Ophthalmology, Hamamatsu Univ Sch of Med, Hamamatsu, Japan
  • N. Hata
    Department of Ophthalmology, Hamamatsu Univ Sch of Med, Hamamatsu, Japan
  • M. Kato
    Department of Ophthalmology, Hamamatsu Univ Sch of Med, Hamamatsu, Japan
  • M. Nakamura
    Department of Ophthalmology, Nagoya Univ Sch of Med, Nagoya, Japan
  • Y. Miyake
    Department of Ophthalmology, Nagoya Univ Sch of Med, Nagoya, Japan
  • Footnotes
    Commercial Relationships  Y. Hotta, None; N. Tomita, None; K. Koide, None; T. Tsuchiya, None; N. Hata, None; M. Kato, None; M. Nakamura, None; Y. Miyake, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1471. doi:
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    • Get Citation

      Y. Hotta, N. Tomita, K. Koide, T. Tsuchiya, N. Hata, M. Kato, M. Nakamura, Y. Miyake; Sectorial Fundus Albipunctatus Is Not Associated With RDH5 Gene Mutation . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1471.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To report a case of sectorial fundus albipunctatus not associated with RDH5 gene mutation. Methods: A 51-year-old woman showed multiple yellow-white flecks similar to those of fundus albipunctatus in only the upper half of the retina in both eyes. We performed clinical, electrophysiological, and molecular genetic examinations. Results: Her visual acuities were 20/20 with –2.5D -0.75D X 90° OD, and 20/20 with –1.75D -0.75D X 95° OS. No remarkable visual field defect was detected by the Goldmann perimetry. Fluorescein angiography showed diffuse irregular hypofluorescence which did not correspond with the fleck lesions. The Goldmann-Weeker adaptometer test revealed that visual threshold of the upper retina was approximately 0.6 to 0.8 log units higher than that of the lower retina. No abnormal pattern and differences in the full-field and multifocal ERG. No mutations of the RDH5 gene was detected in exons 2-5 as well as the flanking intron sequences. Conclusions: To our knowledge, this is the first report of sectorial fundus albipunctatus, and the flecks may be not caused by the RDH5 gene mutation.

Keywords: retinal degenerations: hereditary • genetics • dark/light adaptation 
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